Seroprevalance of chlamydophila pneumoniae in patients with alzheimer's disease and vascular dementia Alzheimer ve vasküler demanslı hastalarda chlamydophila pneumonaie seroprevalansı

ECEMİŞ T., MAVİOĞLU H., ÖZKÜTÜK N., AKÇALI S., Karaçam M., Şanlidaǧ T.

Journal of Neurological Sciences, cilt.27, sa.4, ss.400-406, 2010 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2010
  • Dergi Adı: Journal of Neurological Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.400-406
  • Anahtar Kelimeler: Alzheimer's disease, C. pneumoniae, Seroprevalance, Vascular dementia
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

In recent years, it was been argued that Chlamydophila pneumoniae, which is an intracellular pathogen capable of causing chronic infection, might be effective in some forms of dementia, an argument confirmed or rejected by some studies. The objective of this study was to determine if there was an association between C. pneumoniae infection and Alzheimer's disease and vascular dementia. We tested 54 patients with Alzheimer and 29 patients with vascular dementia and 50 controls for C. pneumoniae IgG and IgA antibodies and analyzed the results statistically. C. pneumoniae IgG antibodies were found in 25 patients (49.2%) with Alzheimer's disease, 15 patients (51.8%) with vascular dementia and 22 controls (44%) whereas 6 patients (11.1%), 2 patients (6.9%) and 3 controls (6%), respectively, tested positive for IgA. It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.