Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

Moharrami P., Unak P., Guldu O. K., Medine E., Gumuser G., Bilgin E. S., ...Daha Fazla

Journal of Radioanalytical and Nuclear Chemistry, cilt.314, sa.3, ss.2609-2620, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 314 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10967-017-5630-2
  • Dergi Adı: Journal of Radioanalytical and Nuclear Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2609-2620
  • Anahtar Kelimeler: Breast cancer, Cancer imaging, Diethylstilbestrol, Lung cancer, Prostate cancer, Quantum dot nanoparticles
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.