Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

Moharrami P., Unak P., Guldu O. K., Medine E., Gumuser G., Bilgin E. S., ...More

Journal of Radioanalytical and Nuclear Chemistry, vol.314, no.3, pp.2609-2620, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 314 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1007/s10967-017-5630-2
  • Journal Name: Journal of Radioanalytical and Nuclear Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2609-2620
  • Keywords: Breast cancer, Cancer imaging, Diethylstilbestrol, Lung cancer, Prostate cancer, Quantum dot nanoparticles
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.