Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Pediatri, cilt.19, sa.2, ss.144-147, 2010 (Scopus)
Nicolau syndrome is a rare complication following in tramuscular injection of various drugs, and manifests as excruciating pain after injection. It is characterized by local aseptic, cutaneous, and sometimes muscular necrosis at injection site. Intra-arterial or para-arte rial drug in jection and acute vasospasm caused by of fending drug are the most acceptable hypothesizes in pathogenesis. Local care, heparin, vasoactive agents, hyperbaric oxygen and surgical interventions can be used as treatment modalities. In this report, we described two cases following benzathine penicillin injection at middle part of left thigh (case 1: 12-ye ar-oldboy) and procaine penicillin injection at middle part of lateral surface of the left thigh (cases 2: 5-ye ars-old girl) because of its rarity. The cases were treated with low molecular weight heparin (case 1) and by local care (case 2), uneventfully. In conclusion, applications of standard drug injection rules are essential in prevention from Nicolau syndrome. The cases with Nicolau syndrome should be monitored closely, and therapy should be started immediately in severecases. Copyright © 2010 by Türkiye Klinikleri.