Differential pulse polarographic determination of Enalapril maleate

Elmali F., ALPDOĞAN G., Aycan Ş., Sungur S.

Turkish Journal of Chemistry, vol.27, no.1, pp.65-69, 2003 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2003
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.65-69
  • Keywords: differential pulse polarography, high performance liquid chromatography, enalapril maleate, tablets
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

A differential pulse polarographic (DPP) method has been developed for the quantitative analysis of enalapril maleate. Enalapril maleate gives a peak at -1.4 V in methanol. A calibration curve was constructed for the 20 -100 μg ml-1 concentration range. As a reference method, a reversed phase high performance liquid chromatographic procedure has been developed. Commercially available tablets were analysed by the two methods. Statistical evaluations indicated that there was no significant difference between the mean values and precisions of the two methods at a 95% confidence level.