Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines

Uzaras C., AVCIBAŞI U., Demiroğlu H., Medine E. İ., Kılçar A. Y., Müftüler F. Z. B., ...Daha Fazla

Journal of Radioanalytical and Nuclear Chemistry, cilt.307, sa.1, ss.131-140, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 307 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-015-4119-0
  • Dergi Adı: Journal of Radioanalytical and Nuclear Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.131-140
  • Anahtar Kelimeler: Daoy and A549 cancerous cell lines, Diphenylhydantoin, Epilepsy, Phenytoin, Radiolabeling, U-87 MG
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

The aim of this study is to determine the incorporations of PHT radiolabeled with 131I (131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of 131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of 131I, 131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of 131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, 131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.