Akademik Veri Yönetim Sistemi
37th European Congress of Pathology, Vienna, Avusturya, 6 - 10 Eylül 2025, ss.321-322, (Özet Bildiri)
Background & Objectives: The increasing use of imaging tech niques has led to a rise in the detection of liver masses, making the accurate diagnosis of their nature crucial. While advances in radiol ogy have reduced the need for liver biopsy in hepatocellular carci noma (HCC), biopsy remains essential for diagnosing various liver lesions, including metastatic tumours. This study aims to evaluate diagnostic role of liver core needle biopsies, with a particular focus on identifying the primary tumour in cases of 9 liver metastases with an unknown primary. Methods: A total of 406 liver core needle biopsies performed between 2017 and 2022 due to liver masses were reviewed. Clinical, radiologi cal, histopathological and immunohistochemical data for primary and metastatic tumours were evaluated. Results: Of the 406 liver biopsy cases, a significant portion were diag nosed as metastatic lesions, with common primary sites identified as gastrointestinal, lung, and breast cancers. Immunohistochemical mark ers showed varying positivity rates across different tumour types, with GATA-3, CDX2, and TTF1 proving particularly useful in distinguish ing tumour origin. While some markers were highly specific, others exhibited variable expression, highlighting complexity of diagnosing metastatic tumours with unknown primaries. Conclusion: Liver biopsy remains a crucial diagnostic tool in the iden tification of primary and metastatic liver tumours, especially when the primary site is unknown. Immunohistochemical analysis enhances the accuracy of diagnosis, though it should be used in conjunction with clinical and radiological data. This study underscores the importance of a multidisciplinary approach in managing liver masses, with further research needed to optimize diagnostic strategies and improve patient outcomes.