Akademik Veri Yönetim Sistemi
Supportive Care in Cancer, cilt.33, sa.4, 2025 (SCI-Expanded)
Background: Lung cancer is a malignancy marked by low treatment response rates and poor survival outcomes, despite significant advancements in diagnostic and therapeutic approaches. This study aims to examine the impact of dietary habits and physical activity levels on chemotherapy response and survival in patients diagnosed with advanced-stage non-small cell lung cancer. Methods: Patients diagnosed with stage IV non-small cell lung cancer and scheduled to receive platinum-based chemotherapy as the initial treatment were included in the study. Sociodemographic and cancer-related characteristics were documented. At the beginning of treatment, the patients’ dietary habits and physical activity levels were evaluated using the “Mediterranean Diet Adherence Scale,” the “International Physical Activity Questionnaire,” and the “Food Consumption Frequency Form,” while their average daily step count was calculated. The study investigated the relationships between dietary habits and physical activity levels with treatment response, 6-month survival, progression-free survival, and chemotherapy-related side effects. Results: The study included a total of 37 patients, 35 of whom were male, with a mean age of 63.49 years. The 6-month survival rate among these patients was 81.1%. In terms of treatment response, 35.1% of patients experienced disease progression, 54.1% demonstrated partial regression, and 8.1% achieved complete regression. Notably, the 6-month survival rate was significantly higher in minimally physically active patients compared to inactive patients (p = 0.022). Furthermore, patients adhering to the Mediterranean diet exhibited a significantly higher 6-month survival rate compared to those who did not follow the diet (p = 0.019). High adherence to the Mediterranean diet was also associated with a significantly lower incidence of chemotherapy-related gastrointestinal side effects (p < 0.001). Conclusion: This study demonstrated that physical activity and adherence to the Mediterranean diet positively impact 6-month survival and reduce the incidence of chemotherapy-related side effects.