Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles

Türkkanı G., Güngör B., Cetin O., İÇHEDEF Ç., PARLAK Y., GÜMÜŞER F. G., ...More

Journal of Radioanalytical and Nuclear Chemistry, vol.332, no.11, pp.4695-4704, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 332 Issue: 11
  • Publication Date: 2023
  • Doi Number: 10.1007/s10967-023-08975-5
  • Journal Name: Journal of Radioanalytical and Nuclear Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, INSPEC, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.4695-4704
  • Keywords: Azathioprine, Solid lipid nanoparticles, Magnetic nanoparticles, Radiolabeling, In vitro, In vivo
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract: [Figure not available: see fulltext.]