Antineovascular effect of α-interferon on corneal neovascularization in rats

Öztürk F., Sobaci G., Sami Ilker S., Can C.

Annals of Ophthalmology, vol.33, no.1, pp.35-39, 2001 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1007/s12009-001-0070-5
  • Journal Name: Annals of Ophthalmology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.35-39
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Clinical and histologic effects of topical recombinant α-interferon (IFN), systemic IFN, topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to the burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.