The role of circadian rhythm genes in cancer Kanserde sirkadiyan ritim genlerinin rolü

ATMACA İLHAN H., Uzunoǧlu S.

Journal of Cell and Molecular Biology, cilt.9, sa.2, ss.1-10, 2011 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2011
  • Dergi Adı: Journal of Cell and Molecular Biology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.1-10
  • Anahtar Kelimeler: Cancer, Circadian rhythm, Cryptochrome, Molecular clock, Period
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Circadian (In Latin: Circa=around, Diem=day) rhythm describes the processes of 24 hour oscillations in the living systems. At the cellular level, circadian rhythm is controlled by a molecular network with positive and negative feedbacks. The known critical elements in the positive feedback loop are Clock and Bmal1; the ones in complementary negative feedback are mainly Period and Cryptochrome genes. In cancer, which is an important health problem today, dysregulation of circadian rhythm is an important risk factor. In this review, circadian rhythm genes involved in cell proliferation, apoptosis, DNA repair, metabolism, detoxification and response to DNA damage and their roles in cancer development are summarized.