Influence of radiation exposure during radiotherapy: Evidence for the increase of versican and heparin-binding EGF-like growth factor concentrations

ÖZBİLGİN M. K., Aktas C., Uluer E. T., Buyukuysal M. C., Gareveran M. S., KURTMAN C.

Analytical and Quantitative Cytology and Histology, cilt.38, sa.2, ss.126-132, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2016
  • Dergi Adı: Analytical and Quantitative Cytology and Histology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.126-132
  • Anahtar Kelimeler: Cancer, Carcinogens, HB-EGF, Heparin-binding EGF-like growth factor, Radiation, Radiotherapy, Targeted radiotherapy, Versican
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.