Exploration of the efficacy of placebo, lornoxicam and alverine citrate+simethicone in the treatment of primary dysmenorrhea Primer dismenore tedavisinde plasebo, lornoxicam, ve alverine citrate+simethicone'un etkinliklerinin karşilaştirilmasi

Özbay K., Inanmiş R. A., Deveci S., Yardim T.

Jinekoloji ve Obstetrik Dergisi, vol.20, no.3, pp.158-161, 2006 (Scopus, TRDizin) identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2006
  • Journal Name: Jinekoloji ve Obstetrik Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.158-161
  • Keywords: Alverine Citrate, Dysmenorrhea, Lornoxicam, Placebo, Simethicone
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

OBJECTIVE: To compare the efficacy of lornoxicam, alverine citrate+simethicone and placebo in the treatment of dysmenorrhea. STUDY DESIGN: 33 patients who were admitted to our clinic because of primary dysmenorrhea were treated with lornoxicam, alverine citrate+symethicone and placebo for 2 cycles for each drug. The efficacy of treatment was evaluated with the visual analog scale (VAS). RESULTS: Placebo was found ineffective (p=0.989), lornoxicam and alverine citrate were determined to be effective in the treatment of primary dysmenorrhea (p values respectively p=0.000, p=0.001). CONCLUSION: Our results are inline with the literature supporting the use of NSAID in the treatment of primary dysmenorrhea. Due to its smooth muscle relaxant and analgesic effect, alverine citrate seems to be useful as a supplementary drug in the treatment of primary dysmenorrhea. However larger series of patients are needed to determine the effect of alverine citrate on primary dysmenorrhea more precisely.