Akademik Veri Yönetim Sistemi
Human Reproduction, cilt.16, sa.11, ss.2305-2309, 2001 (SCI-Expanded)
Background: The expression of integrin molecules on the endometrium suggest that certain integrins may participate in the cascade of molecular events leading to successful implantation. A prospective, controlled study was carried out to investigate the effect of clomiphene citrate (CC) on secretions of β1, α3 and αv integrin molecules in the endometrium of patients with unexplained infertility during the implantation window. Methods: A total of 40 endometrial samples was evaluated in both spontaneous (n = 13) and ensuing clomiphene-treated cycles (100 mg on days 5-9) and also from fertile women serving as controls (n = 14) during postovulatory 7th or 8th day of menstrual cycle. A semiquantitative grading system (H-score) was used to compare the immunohistochemical staining intensities. Endometrial thickness and serum oestradiol and progesterone concentrations were also measured on the day of sampling. Results: Staining of αv but not β1 and α3 integrins was significantly less intense in infertile cases than fertile control cases (1.42 ± 0.12 versus 2.21 ± 0.13 respectively, P = 0.012) and this was not restored to normal concentrations with treatment. Conclusions: Our study indicated that cc treatment significantly decreased the endometrial thickness and increased oestradiol and progesterone concentrations. However, secretion of αv, β1 and α3 integrin molecules, which might play a role in implantation, was not affected.