Radiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

Uyaroğlu Ö., Demiroğlu H., Topal G., PARLAK Y., Gül Gümüşer F., Uluer Türköz E., ...More

Medicinal Chemistry Research, vol.26, no.12, pp.3149-3157, 2017 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1007/s00044-017-2009-4
  • Journal Name: Medicinal Chemistry Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3149-3157
  • Keywords: 99mTc, Infection imaging agent, S. aureus, Sulfamethoxazole
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

The aim of this study was to prepare 99mTc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99mTc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 ± 3.07% and remained constant at more than 93 ± 0.1% even in serum for 240 min after radiolabeling. 99mTc-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. 99mTc-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.