The cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line

KURT O., ÖZDAL KURT F., Tuʇlu M., Akçora C.

Biotechnic and Histochemistry, cilt.89, sa.8, ss.568-576, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/10520295.2014.917199
  • Dergi Adı: Biotechnic and Histochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.568-576
  • Anahtar Kelimeler: antiproliferative activity, apoptosis, cytotoxicity, Halimeda tuna, Jania longifurca, MCF-7 cell line, neurotoxicity, Petalonia fascia
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

We investigated the cytotoxic, neurotoxic, apoptotic and antiproliferative effects of extracts from Petalonia fascia, Jania longifurca and Halimeda tuna on the MCF-7 breast cancer cell line. J. longifurca extracts were more toxic than those of P. fascia and H. tuna. The algal extracts showed significant toxic effects at different dilutions. The toxic effects were due to increased oxidative stress and resulted in apoptosis. Algal toxicity may exert negative effects through the food chain or by direct interaction. Algal toxicity also has potential for cancer therapy. The toxic effects that we observed may be especially important for therapy for breast tumors.