Diabetes mellitus due to olanzapine use: A case report Olanzapin'e baǧli diabetes mellitus: Bir olgu sunumu

Danaci A. E., Mizrak S., HEKİMSOY Z., Içelli I.

Klinik Psikofarmakoloji Bulteni, cilt.13, sa.2, ss.94-96, 2003 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2003
  • Dergi Adı: Klinik Psikofarmakoloji Bulteni
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.94-96
  • Anahtar Kelimeler: Diabetes mellitus, Olanzapine, Schizophrenia, Side effect
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Olanzapine, a serotonin-dopamine-receptor antagonist, is an atypical antipsychotic agent used to treat schizophrenia and other psychotic disorders. It has relatively low frequency of side effects such as sedation, orthostatic hypotension, extrapyramidal symptoms, and anticholinergic side effects. Here, a 32-years-old female patient with schizophrenia who developed diabetes after 3 years of olanzapine treatment is presented. Due to lack of family history and immune marker positivity in the occurrence of diabetes, the condition was attributed to olanzapine treatment. After discontinuation of the treatment DM was improved. Controlled studies are necessary both to elucidate the mechanism by which olanzapine can cause dysregulation of glucose homeostasis, and to develop guidelines for the use of olanzapine in patients with known as well as in patients with risk factors for diabetes.