Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism Varfarin kullanan hastada travma olmaksizin gelisen alt ekstremite kas hematomu ve VKORC1, CYP2C9 gen polimorfizmi ile iliskisi

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Emren S. V., Eren N. K., ÖZYILDIRIM S., Bülbül H., USLU S.

Turkish Journal of Thoracic and Cardiovascular Surgery, vol.23, no.1, pp.150-153, 2015 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 23 Issue: 1
• Publication Date: 2015
• Doi Number: 10.5606/tgkdc.dergisi.2015.10141
• Journal Name: Turkish Journal of Thoracic and Cardiovascular Surgery
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.150-153
• Keywords: Bleeding, Gene polymorphism, Warfarin
• Manisa Celal Bayar University Affiliated: No

Abstract

Warfarin is the most frequently used oral anticoagulant agent today. Warfarin response can be affected by environmental factors such as dietary habits and drugs as well as genetic factors, and this might increase bleeding risk. In this article, we report a 79-year-old male patient who developed nontraumatic hematoma of left lower extremity despite using low-dose warfarin, and whose genetic analyses revealed CYP2C9*2*3, VKORC1 AA and VKORC1 TT gene polymorphisms.