Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism Varfarin kullanan hastada travma olmaksizin gelisen alt ekstremite kas hematomu ve VKORC1, CYP2C9 gen polimorfizmi ile iliskisi

Emren S. V., Eren N. K., ÖZYILDIRIM S., Bülbül H., USLU S.

Turkish Journal of Thoracic and Cardiovascular Surgery, cilt.23, sa.1, ss.150-153, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5606/tgkdc.dergisi.2015.10141
  • Dergi Adı: Turkish Journal of Thoracic and Cardiovascular Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.150-153
  • Anahtar Kelimeler: Bleeding, Gene polymorphism, Warfarin
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Warfarin is the most frequently used oral anticoagulant agent today. Warfarin response can be affected by environmental factors such as dietary habits and drugs as well as genetic factors, and this might increase bleeding risk. In this article, we report a 79-year-old male patient who developed nontraumatic hematoma of left lower extremity despite using low-dose warfarin, and whose genetic analyses revealed CYP2C9*2*3, VKORC1 AA and VKORC1 TT gene polymorphisms.