ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF <i>N</i>,<i>N</i>'-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT'S METAL COMPLEXES

Özbek H., Çinar S., OSKAY M., Aydemir T., Demirhan F.

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, cilt.66, sa.3, ss.5237-5241, 2021 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 3
  • Basım Tarihi: 2021
  • Dergi Adı: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Fuente Academica Plus, CAB Abstracts, Chemical Abstracts Core, Veterinary Science Database
  • Sayfa Sayıları: ss.5237-5241
  • Anahtar Kelimeler: Antimicrobial activity, Ferrocene, Schiff base, Schiff base metal complex, SOD-like activity
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

The synthesized N,N'-bis(ferrocenylmethylene)ethylenediamine Schiff base and it's metal complexes were screened in vitro for antimicrobial activity against two Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative (Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans. MIC values of the compounds ranged from 27 to 533 mu g/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 mu g/mL). The lowest MIC for C. albicans was obtained 107 mu g/mL. The superoxide dismutase activity of Schiff base and it's metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 mu m IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.