Effects of cilazapril on endothelial function and pulmonary hypertension in patients with congestive heart failure.

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Tavli T., Gocer H.

Japanese heart journal, vol.43, no.6, pp.667-674, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1536/jhj.43.667
  • Journal Name: Japanese heart journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.667-674
  • Keywords: endothelial function, cilazapril, pulmonary hypertension, congestive heart failure
  • Open Archive Collection: AVESIS Open Access Collection
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Flow-mediated vasodilation (FMV), brachial artery flow (BAF), and brachial artery diameter were evaluated in 30 patients with congestive heart failure before and after cilazapril treatment. While mean pulmonary artery pressure and pulmonary capillary wedge pressure decreased significantly, flow-mediated vasodilation and left ventricular ejection fraction increased significantly following cilazapril administration (P < 0.001). Brachial artery diameter and brachial artery flow did not change following the treatment period (P > 0.05). In conclusion, short-term cilazapril administration improved endothelial function and pulmonary pressure in patients with congestive heart failure.