Comparison of the osteogenic differentiation capacity of adipose tissue derived mesenchymal stem cells from humans and rats

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Erden Tayhan S., Taşdemir Ş., Deliloğlu Gürhan S. İ., Mir E.

Turkish Journal of Biology, vol.40, no.5, pp.1090-1095, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.3906/biy-1507-128
  • Journal Name: Turkish Journal of Biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1090-1095
  • Keywords: Osteogenic differentiation, mesenchymal stem cell, adipose tissue, human, rat
  • Open Archive Collection: AVESIS Open Access Collection
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they are quite promising for orthopedic clinical trials. The present study aimed to compare the osteogenic differentiation conditions of MSCs from human adipose tissue (hADMSC) and those of MSCs from rat adipose tissue (rADMSC). Therefore, differentiation experiments with five different media and two (human and rat) ADMSC types were performed and the mineralization responses of hADMSCs and rADMSCs were different.