Click Reactivity of Azide-Modified Polyvinyl Chloride as an Entry to Glycopolymer Scaffolds

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AY E., YENİL N.

Croatica Chemica Acta, vol.94, no.3, pp.167-176, 2021 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5562/cca3883
  • Journal Name: Croatica Chemica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Directory of Open Access Journals
  • Page Numbers: pp.167-176
  • Keywords: protected-sugar alkynes, PVC-N-3, click reactions, 1,2,3-triazole
  • Open Archive Collection: AVESIS Open Access Collection
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

We report the synthesis of new carbohydrate/triazole polymers based on poly(viny chloride) (PVC). Azide incorporation into commercially available PVC was carried out using nucleophilic substitution and Cu-catalyzed reaction of the resulting PVC-N3 using three alkynylcontaining acetonide-protected monosaccharides (based on D-glucose and D-galactose) provided a set of PVC-based polymers incorporating a triazolyl linkage with monosaccharide moieties present on the periphery. Modified polymers were characterized by using Fourier transform infrared (FT-IR), Nuclear Magnetic Resonance (1H-NMR and 13C-NMR) spectroscopy, together with thermogravimetric and surface morphological analysis.