Comparison of the Rate of Induced Intrinsic Pathway of Apoptosis on COLO-320 and COLO-741

Hincal E., Soykut G., Tijjani Saad F., Vatansever S., Abdullahi Baba I., Çalış İ., ...More

4th International Conference on Analysis and Applied Mathematics, ICAAM 2018, Mersin, Turkey, 6 - 09 September 2018, vol.351, pp.161-169, (Full Text) identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 351
  • Doi Number: 10.1007/978-3-030-69292-6_12
  • City: Mersin
  • Country: Turkey
  • Page Numbers: pp.161-169
  • Keywords: Basic reproduction number, HIV, Mathematical model, Stability analysis
  • Manisa Celal Bayar University Affiliated: No

Abstract

Mathematical modeling is a key tool in understanding complicated behavior of large signal transduction networks. In this paper a mathematical model is developed to understand the complex signaling behavior of induced apoptosis in Colo-320 and Colo-741 cell lines. The model studies the intrinsic pathway of apoptosis induced by Apaf-1, Cyt-c, and Caspase 3. Experimentally these tests were carried out five times for three groups; namely Control, DCM and Aqueous groups. The main aim is to compare the rate of the occurrence of apoptosis in the two cells Colo-320 and Colo-741 using experimental data. Numerical results reveal that apoptosis takes place at the same time in DCM for Colo-320 and Colo-741, but slightly faster in Aqueous group for Colo-320. It was observed that it took place between the 5–7th h in all the cases.