Investigation of therapeutic efficacy of intraperitoneal ketamine administration on the brain vascular system in rats with traumatic brain injury

Yapici T., MENTEŞE B., PEKMEZCİ M. Y., Aygunduz Yapici N., KUTLU N., METE M., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.101, sa.4, ss.226-239, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 4
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/10520295.2026.2645058
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, MEDLINE
  • Sayfa Sayıları: ss.226-239
  • Anahtar Kelimeler: EEG, EGR-1, HMGB1, hypertonic saline, ketamine, mannitol, RAGE, S100b, traumatic brain injury
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Traumatic brain injury (TBI) is a condition characterized by high morbidity and mortality. This study investigated the therapeutic effects of ketamine on TBI through electrophysiological and immunohistochemical methods in a model of 30 rats divided into five equal groups. Following trauma, ketamine, mannitol, and hypertonic saline treatments were administered. Analyses conducted on the 10th day post-trauma revealed that ketamine most effectively reduced the expressions of HMGB1, S100b, RAGE, and EGR-1 across all treatment groups. Furthermore, EEG findings demonstrated a significant decrease in Delta/Alpha and Delta/Beta ratios in the ketamine group. These results suggest that ketamine exerts a healing effect on brain tissue by suppressing pathological delta waves and modulating the HMGB1/S100b/RAGE/EGR-1 signaling pathway.