The role of biomarkers of innate and adaptive immunity in the early detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus

TÜREDİ YILDIRIM A., Bayar N. T. I., Yiğit Y., ERSOY B.

Journal of Diabetes and its Complications, cilt.39, sa.9, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 9
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.jdiacomp.2025.109090
  • Dergi Adı: Journal of Diabetes and its Complications
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, MEDLINE
  • Anahtar Kelimeler: Adolescent, Children, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Type 1 diabetes mellitus
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Aims: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are biomarkers linked to microvascular complications in adult diabetics. This study aimed to assess whether NLR and PLR, which increase in chronic inflammation, could aid in early detection of diabetic nephropathy (DN) in children and adolescents with Type 1 diabetes mellitus (T1DM). Methods: The study included 90 children and adolescents with T1DM and 30 healthy controls. Microalbuminuria, defined as urine albumin >20 μg/min, was used to indicate early DN. Participants were grouped by diabetes duration: 0–60 months, 61–120 months, and >120 months. Results: NLR was significantly higher in patients with microalbuminuria compared to controls and those without microalbuminuria (p10 years. Positive correlations were observed between urinary albumin and NLR (r = 0.274, p = 0.003) and between PLR and diabetes duration (r = 0.286, p = 0.006). For early DN diagnosis, an NLR threshold of 1.675 showed 60 % specificity and 84.2 % sensitivity. Conclusions: NLR outperformed PLR in early DN detection and may prompt timely urine albumin testing in children with T1DM. Further studies are needed to confirm these results.