Toll-like receptor 2 expression and peripheral blood CD4+/CD8+ T cell ratio in COPD

Ulutaş G. Ş., ÖZGEN ALPAYDIN A., TANELİ F., Çetinkaya C., ULMAN C., Güvenç Y., ...Daha Fazla

Turk Toraks Dergisi, cilt.15, sa.3, ss.106-111, 2014 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/ttd.2014.3842
  • Dergi Adı: Turk Toraks Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.106-111
  • Anahtar Kelimeler: COPD, inflammation, innate immunity, CD4+/CD8+ T lymphocytes, TLR
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

OBJECTIVES: We aimed to evaluate toll-like receptor 2 (TLR-2) expression on monocytes and peripheral blood CD4+/CD8+ T cell ratio, as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients. MATERIAL AND METHODS: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population. RESULTS: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034). CONCLUSION: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction. © 2014 by Turkish Thoracic Society.