Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses

Yenil N., Ay E., Ay K., Oskay M., Maddaluno J.

Carbohydrate Research, cilt.345, sa.11, ss.1617-1621, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 345 Sayı: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.carres.2010.03.043
  • Dergi Adı: Carbohydrate Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1617-1621
  • Anahtar Kelimeler: Amino sugars, Antimicrobial activity, Chloraloses, Trichloroethylidene acetals
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-β-l-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-α-d-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans. © 2010 Elsevier Ltd. All rights reserved.