Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey


Sarikurkcu C., ÖZER M. S., İSTİFLİ E. S., Sahinler S. S., Tepe B.

South African Journal of Botany, cilt.143, ss.393-405, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.sajb.2021.03.020
  • Dergi Adı: South African Journal of Botany
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.393-405
  • Anahtar Kelimeler: Antioxidant activity, Phytochemical composition, Sideritis leptoclada, Tyrosinase inhibitory, α-Amylase inhibitory
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent.