Atherogenic profile in preeclampsia

Var A., KUŞÇU N. K., Koyuncu F., Uyanik B. S., ONUR E., Yildirim Y., ...More

Archives of Gynecology and Obstetrics, vol.268, no.1, pp.45-47, 2003 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 268 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1007/s00404-002-0317-4
  • Journal Name: Archives of Gynecology and Obstetrics
  • Journal Indexes: Scopus
  • Page Numbers: pp.45-47
  • Keywords: Apolipoprotein A-1, Apolipoprotein B, Lipoprotein(a), Malonyldialdehyde, Preeclampsia
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9±1.4 and 35.5±0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis.