Interleukin-6 levels in hyperemesis gravidarum

KUŞÇU N. K., Yildirim Y., Koyuncu F., Var A., Uyanik B. S.

Archives of Gynecology and Obstetrics, vol.269, no.1, pp.13-15, 2003 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 269 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1007/s00404-002-0412-6
  • Journal Name: Archives of Gynecology and Obstetrics
  • Journal Indexes: Scopus
  • Page Numbers: pp.13-15
  • Keywords: Hyperemesis, IL-6, Pregnancy, Thyroid
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Introduction: Hyperemesis gravidarum (HG) is associated with higher levels of serum β-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of β-hCG from trophoblastic cell line. Methods: We measured serum levels of IL-6, thyroid hormones and β-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups. Results: There was a significant difference in β-hCG (p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with β-hCG (r=0.38 and p=0.13).