Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.30, sa.2, ss.808-811, 2010 (SCI-Expanded)
Radiation pneumonitis and subsequent pulmonary fibrosis are among the serious complications of thoracic irradiation and can have severe implications on patients' quality of life. Systemic corticosteroids are commonly used agents to treat radiation pneumonitis. However, the potential adverse effects of systemic corticosteroids, particularly in growing children, are consid-erable. An infant with lung metastatic Ewing sarcoma developed severe radiation pneumonitis following chemoradiotherapy. Systemic prednisolone was started first. However, due to the prolonged need for corticosteroid therapy, inhaled budesonide was administered with reduced systemic corticosteroid dose in an attempt to avoid the adverse effects of systemic corticosteroid treatment. The treatment was then continued exclusively with budesonide with a good clinical response. To our knowledge, this is the first pediatric case reported to benefit from inhaled steroids for severe radiation pneumonitis. This response suggested that inhaled steroids might serve as a adjunct or even an alternative to systemic corticosteroids in radiation pneumonitis. © 2010 by Türkiye Klinikleri.