Akademik Veri Yönetim Sistemi
BMC Oral Health, cilt.25, sa.1, 2025 (SCI-Expanded)
Background: Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fluid (GCF) of individuals with different periodontal conditions. Methods: GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA. Results: Clinical parameters were significantly higher in periodontitis groups compared to gingivitis and healthy groups (p < 0.001). GCF EF1-Ɣ total amount differed among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p < 0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p < 0.001). GCF ANXA1 and CA1 levels were similar across study groups (p > 0.05). Conclusion: Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease.