The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

Inan S. Y., Aksu F., Baysal F.

European Journal of Pharmacology, cilt.407, sa.1-2, ss.159-164, 2000 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 407 Sayı: 1-2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0014-2999(00)00736-6
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.159-164
  • Anahtar Kelimeler: 4-aminopyridine, 3,4-diaminopyridine, apamin, passive avoidance, (mouse)
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V.