The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

Inan S. Y., Aksu F., Baysal F.

European Journal of Pharmacology, vol.407, no.1-2, pp.159-164, 2000 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 407 Issue: 1-2
  • Publication Date: 2000
  • Doi Number: 10.1016/s0014-2999(00)00736-6
  • Journal Name: European Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.159-164
  • Keywords: 4-aminopyridine, 3,4-diaminopyridine, apamin, passive avoidance, (mouse)
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V.