Determination of Post-Exposure Prophylaxis Regimen in the Prevention of Potential Pediatric HIV-1 Infection by the Multi-criteria Decision Making Theory

SAYAN M., Sultanoglu N., Uzun B., Yildirim F. S., Sanlidag T., Ozsahin D. U.

2019 Advances in Science and Engineering Technology International Conferences, ASET 2019, Dubai, Birleşik Arap Emirlikleri, 26 Mart - 10 Nisan 2019, (Tam Metin Bildiri) identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/icaset.2019.8714442
  • Basıldığı Şehir: Dubai
  • Basıldığı Ülke: Birleşik Arap Emirlikleri
  • Anahtar Kelimeler: antiretroviral-agents, decision making, fuzzy logic, HIV, post-exposure prophylaxis, PROMETHEE
  • Manisa Celal Bayar Üniversitesi Adresli: Hayır

Özet

With the use of fuzzy PROMETHEE method, current study analysed and evaluated the preferred and alternative post-exposure prophylaxis (PEP) regimens that can be used in infants and children. PEP is a combination of anti-HIV drugs that can be prescribed after a possible exposure to HIV infection with the aim of preventing infection. The fuzzy PROMETHEE method is a multi-criteria decision maker technique which allows the mutual comparison of different alternatives in a system. Thus, different PEP regimens were evaluated using this technique with their corresponding parameters. The relative importance (weights) of the used parameters for each criterion was determined by expert's opinions and the use of guidelines. Our study indicated that amongst the PEP regimens, raltegravir+tenofovir/emtricitabine (RAL+TDF/FTC) was found to be the most potent PEP regimen that can be applied in infants and children in necessary situations.