Anticancer potential of viperid snake venoms: challenges and future directions

Çelik Ç., İLHAN M. S.

Toxin Reviews, vol.44, no.3, pp.351-369, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Review
  • Volume: 44 Issue: 3
  • Publication Date: 2025
  • Doi Number: 10.1080/15569543.2025.2525865
  • Journal Name: Toxin Reviews
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, BIOSIS, CAB Abstracts, Environment Index, Food Science & Technology Abstracts, Veterinary Science Database
  • Page Numbers: pp.351-369
  • Keywords: Cancer, cytotoxicity, drug discovery, venom, Viperidae
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Background and Aim: Cancer has become one of the major global health threats. Venoms, used by animals for defense and predation have long intrigued researchers for their potential in treating various diseases, especially snake venoms. These venoms contain various bioactive components studied for pharmacological applications, including anticancer effects. Viperid venoms, in particular, have attracted attention due to their complex composition rich in enzymes such as metalloproteinases, disintegrins, and phospholipases, which are known to affect cancer cell proliferation, angiogenesis, and metastasis. Key Findings and Conclusions: This review compiles findings on the anticancer properties of viperid venoms from Near and Middle-East regions, emphasizing their effects on cancer cell lines. Although in vitro results are promising, no venom-derived drug has yet been approved for cancer treatment. Addressing translational barriers through advanced models and targeted delivery systems may help realize the therapeutic potential of viperid venoms.