The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases

Onder A., Surer Adanir A., GİZLİ ÇOBAN Ö., BİLAÇ Ö., Kara A.

ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, vol.21, no.2, pp.218-221, 2020 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.5455/apd.53708
  • Journal Name: ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Psycinfo, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.218-221
  • Manisa Celal Bayar University Affiliated: No

Abstract

Autism spectrum disorder (ASD) is characterized by deficits in social interactions and communication, and restricted and stereotypic behaviors. A growing body of evidence has identified metabolic pathways and glutamatergic neuro-transmission affecting oxidative stress levels as potential targets of drug development in autism spectrum disorders. N-acetylcysteine (NA C) is an antioxidant that modulate glutamate and reduce oxidative stress, both associated with the pathophysiology of ASD. N-acetylcysteine has been identified as a potential treatment agent for irritability and self-injurious behaviors in autism. In this case report, we report six cases of autism with severe symptoms of irritability and aggression, two of them responded well to N-acetylcysteine treatment, two of them responded partially and while two did not.