Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Rare Presentation of Anklylosing Spondylitis or a Paradoxical Reaction to Secukinumab?

ALTINIŞIK M., Delibay Y., ERDOĞAN M.

Ocular Immunology and Inflammation, vol.32, no.1, pp.120-122, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 32 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1080/09273948.2022.2150225
  • Journal Name: Ocular Immunology and Inflammation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.120-122
  • Keywords: Ankylosing spondylitis, APMPPE, inflammatory chorioretinopathies, posterior uveitis, secukinumab
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Purpose: To describe an atypical presentation of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in a patient with ankylosing spondylitis (AS) receiving secukinumab. Methods: Retrospective chart review. Results: A 48-year-old female patient with AS receiving secukinumab complained of impaired vision in her left eye. Left eye examination revealed multiple yellow-white lesions at the posterior pole and central subfoveal fluid.The lesions regressed without scarring. The case was diagnosed with clinically APMPPE. Conclusion: In AS patients, posterior uveitis can manifest as APMPPE. It should be recorded as an entity to be considered in the differential diagnosis.