8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism

GİDENER S., LePard K. J., Stephens Jr. R. L.

European Journal of Pharmacology, cilt.284, sa.1-2, ss.19-24, 1995 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 284 Sayı: 1-2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0014-2999(95)00331-e
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.19-24
  • Anahtar Kelimeler: 5-HT1A receptor, 8-OH-DPAT ((±)-8-hydroxy-2-(n-dipropylamino)tetralin), Acid, Adrenal gland, Gastrointestinal system, rat
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Serotonin (5-hydroxytryptamine, 5-HT) is a neuroendocrine component of the gastrointestinal tract. 5-HT1A receptors exist both in the brain and have been demonstrated autoradiographically in high density in the rat stomach. However, the physiologic role of 5-HT1A receptors in modulating gastric function is not known. The effect of the selective 5-HT1A receptor agonist, (±)-8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT), on gastric acid secretory function was compared to 5-HT in acute, urethane-anesthetized gastric-fistulated rats during pentagastrin infusion. 5-HT inhibited, but 8-OH-DPAT stimulated, gastric acid secretion in a dose-dependent manner. Bilateral cervical vagotomy or celiac ganglionectomy did not reverse the effect of 8-OH-DPAT on acid secretion. However, the enhancement of acid by 8-OH-DPAT was attenuated by acute adrenalectomy or close intra-arterial administration of spiperone, but not idazoxan. Thus, the data suggest that the selective 5-HT1A receptor agonist 8-OH-DPAT may augment gastric secretory function via an adrenal-dependent mechanism. © 1995.