Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors

Uzunoglu S., Uslu R., TÖBÜ M., Saydam G., Terzioglu E., Buyukkececi F., ...Daha Fazla

Leukemia Research, cilt.23, sa.5, ss.507-512, 1999 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0145-2126(99)00040-5
  • Dergi Adı: Leukemia Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.507-512
  • Anahtar Kelimeler: leukemia, differentiation, methylprednisolone, phosphatase inhibitors, okadaic acid, calyculin A
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

To elucidate the roles of serine/threonine protein phosphatases type 1 (PP1) and type 2A (PP2A) in methylprednisolone-induced differentiation of HL60 cells into granulocytes and K562 cells into monocytes, we examined the effect of serine/threonine protein phosphatase inhibitors, okadaic acid and Cal-A on the proliferation/differentiation of HL60 and K562 cells. Okadaic acid and Cal-A augmented methylprednisolone induced granulocytic differentiation and cell death of HL60 cells and monocytic differentiation and cell death of K562 cells in different dose ranges, respectively. These data suggest an important role of PP1 and PP2A in the mechanism leading to differentiation of leukemic cells.