Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.26, sa.5, ss.226-229, 1998 (Scopus)
The effects of thiopentone and propofol on Natural Killer cell activity were studied by the use of candidial colony inhibition method in venous blood samples from healthy volunteers. Following three hours of incubation mean CFU (colony forming unit) was 72.1 in control group while it was 66.3 and 64.1 CFU in samples containing 15 and 150 μL/mL of thiopentone respectively; and 67 and 63.8 in samples containing 5 and 50 μL/mL of propofol respectively. With small doses of propofol and thiopentone colony inhibition was 7% and 8% respectively while high doses leaded higher inhibitions of 11.5% and 11% respectively. It was concluded that a significant increase in anticandidal activity of natural cytotoxic cells is observed with high concentrations of thiopentone and propofol (p<0.01). However, the increase of this activity is not significant in anaesthetic concentrations used in clinical practice.