Synthesis of 5-fluorouracil dimer containing 2-amino-thiazole group via click reaction 2-amino-tiyazol grubu içeren 5-florourasil dimerinin klik tepkimesi yoluyla sentezi

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Öztürkoğlu G., Ay E., Alp H., Ay K.

El-Cezeri Journal of Science and Engineering, cilt.8, sa.1, ss.315-332, 2021 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.31202/ecjse.789749
  • Dergi Adı: El-Cezeri Journal of Science and Engineering
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.315-332
  • Anahtar Kelimeler: 5-FU, Anticancer, Click reaction, Molecular hybridization, Triazole
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Since cancer is one of the leading diseases that cause human deaths in the world, the synthesis of anticancer or new compounds with fewer side effects is important. 5-Fluorouracil (5-FU) is one of the oldest compounds used for chemotherapy. In this study, 1,2,3-triazole bridge containing compound 4, which could have potential anticancer properties, was synthesized via the click reaction from the 5-FU and 2-aminothiazole using the molecular hybridization approach. The structural elucidation of the new compound was carried out using modern spectroscopic methods such as FTIR,1H,13C,19F, COSY, HSQC, HMBC and TOF-MS.