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International Journal of Radiation Research, vol.18, no.3, pp.571-578, 2020 (SCI-Expanded, Scopus)
Background: Adrenomedullin (AM) and its receptor, receptor actvity-modifying protein (RAMP) 2 have pleiotropic regulatory functons in normal tssue and cancer tssue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investgate a possible role of AM and RAMP2 in the radiaton exposure in the normal lung tssue. M aterial s and Methods: Four groups with 6 male adult Swiss Albino mice per group were investgated. The mice were subjected to a 500 cGy single-dose radiaton exposure in the total body radiaton device and lung tssues were collected. 1, 2, and 7 days after radiaton exposure, with 1 reference group which was not exposed to radiaton. Results: The general histology and the immunohistochemistry of the tssue samples prepared with ant-AM, ant-RAMP2, and monoclonal antbodies were investgated, yielding a statstcally significant increase for AM on day 3 and for RAMP2 on day 1 after radiaton exposure. Conclusion: The observed increase of AM and RAMP2 concentratons in the normal tssue matrix after radiaton exposure may play a role in the side effects of radiotherapy.