Does the anti-migraine drug rizatriptan affect early neural tube development in chick embryos?

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Sayin M., Gurgen G. S., Sayin S. S., Guvenc G., Yuceer N.

Turkish Neurosurgery, cilt.29, sa.1, ss.106-109, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5137/1019-5149.jtn.23431-18.1
  • Dergi Adı: Turkish Neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.106-109
  • Anahtar Kelimeler: Chick embryo, Migraine, Neural tube defect, Pregnancy, Rizatriptan
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

AIM: To investigate the impact of rizatriptan on neural tube development using early chick embryos as a model organism. MATERIAL and METHODS: A total of 36 pathogen-free Leghorn chicken eggs were selected and categorized in three groups: sham, therapeutic, and supra-therapeutic. After 24 hours, the eggs were opened and injected with sterile drugs, and then reclosed using plastic tape. After a period of 72 hours, the eggs were opened and assessed using the Hamburger-Hamilton chick embryology classification method. TUNEL staining was used to identify apoptosis, and hematoxylin-eosin staining was used to investigate neural tube closure. RESULTS: Treatment with rizatriptan significantly slowed down neural tube development. The supra-therapeutic group showed neural tube closure defects. CONCLUSION: Rizatriptan had a negative effect on neural tube closure. Further research is needed to identify a safe and effective drug for treating migraines during pregnancy.