Delayed renal excretion of methotrexate after a severe anaphylactic reaction to methotrexate in a child with osteosarcoma

ÖZGÜVEN A. A., Uysal K., Gunes D., Koroglu T., Gurcu O., Olgun N.

Journal of Pediatric Hematology/Oncology, cilt.31, sa.4, ss.289-291, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/mph.0b013e318199388c
  • Dergi Adı: Journal of Pediatric Hematology/Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.289-291
  • Anahtar Kelimeler: anaphylactic reaction, methotrexate, delayed excretion
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Although methotrexate is an agent widely used in the practice of pediatric oncology, allergic reactions to methotrexate are most unusual. Most of these reactions typically occur after repeated administration. Here, we report a severe anaphylactoid reaction to the first dose of high-dose methotrexate infusion in a child with osteosarcoma who has also experienced a delayed excretion of methotrexate. Clinicians must be aware of the possibility of a systemic, near-fatal anaphylactic reactions with methotrexate and patients who experience severe anaphylactic reactions should be followed carefully because of the possibility of delayed methotrexate excretion. © 2009 Lippincott Williams & Wilkins Inc.