Maternal serum perlecan levels in women with preeclampsia

Akbas M., Koyuncu F. M., ARTUNÇ ÜLKÜMEN B., TANELİ F., Ozdemir H.

Hypertension in Pregnancy, cilt.39, sa.1, ss.70-76, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10641955.2019.1711390
  • Dergi Adı: Hypertension in Pregnancy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.70-76
  • Anahtar Kelimeler: perlecan, Preeclampsia, severe preeclampsia
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Objective: Perlecan is an extracellular matrix proteoglycan suggested to maintain endothelial functions. We aimed to measure maternal serum perlecan levels in different preeclampsia phenotypes. Methods: This study included 50 women with preeclampsia and 30 healthy pregnant women. Results: Serum perlecan levels were significantly higher (p = 0.016) in preeclamptic women with severe features(n = 23) than preeclampsia patients(n = 27). There were no statistically significant differences in serum perlecan levels between the early-onset preeclampsia(n = 25), late-onset preeclampsia(n = 25), and healthy pregnancies. Conclusion: Our findings suggest that preeclamptic women with severe features have higher serum perlecan levels than women with preeclampsia.