The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients

Keles Yucel Z. P., Afacan B., ATMACA İLHAN H., Kose T., Emingil G.

Oral Diseases, cilt.28, sa.4, ss.1240-1249, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/odi.13820
  • Dergi Adı: Oral Diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1240-1249
  • Anahtar Kelimeler: gingival crevicular fluid, interleukin&#8208, 1beta, periodontitis, saliva, serum, trefoil factor
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to investigate the levels of trefoil factor family (TFF)-1, TFF-3 and interleukin (IL)-1β in gingival crevicular fluid (GCF), saliva and serum of patients with gingivitis, stage 3 periodontitis and healthy individuals. Materials and Methods: A total of 100 individuals consisting of 25 periodontally healthy, 25 gingivitis and 50 stage 3 periodontitis, were enrolled in the study. Clinical periodontal examinations were recorded and GCF, saliva and serum samples were obtained. TFF-1, TFF-3 and IL-1β were measured by ELISA. Results: TFF-1 and TFF-3 levels in both GCF, saliva and serum were higher in periodontitis patients than healthy controls (p <.001) and gingivitis group (p <.01). The levels of these peptides in all biofluids were similar between gingivitis and healthy control groups (p >.05). GCF, saliva and serum IL-1β levels were also higher in periodontitis patients than the controls (p <.01). Periodontitis patients had elevated GCF and saliva IL-β levels than gingivitis group (p <.001). Conclusion: Elevated TFF-1 and TFF-3 levels both locally and systemically in periodontitis in parallel to increased IL-1β levels might suggest that these peptides are involved in host response during the periodontal tissue destruction.