Akademik Veri Yönetim Sistemi
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, cilt.42, sa.1, ss.22-30, 2014 (ESCI, Scopus, TRDizin)
Objectives: Metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. There is evidence of increased platelet activation in MetS. Mean platelet volume (MPV), a determinant of platelet activation, is one of the risk factors for atherothrombosis. Therefore, in MetS patients we investigated the possible association (if any) between subclinical atherosclerosis, as evaluated by carotid intimamedia thickness (CIMT) measurement and MPV. Study design: Seventy-four patients with MetS were enrolled in the study. Patients were divided into two groups according to their CIMT measurements: Group 1, n= 35; CIMT = 1.0 mm, and Group 2, n= 39; CIMT < 1.0 mm. MPV was measured using an automated blood cell counter. Results: The mean MPV level was significantly higher in patients with CIMT = 1.0 mm than in patients with CIMT < 1.0 mm (8.2 +/- 0.7 vs. 7.8 +/- 0.6 fl; p= 0.01). In our study, we observed that platelet counts were statistically significantly lower in CIMT = 1.0 mm group. Conclusion: The risk of atherosclerosis could be shown by following the MPV values in MetS patients. Therefore, the results of our study suggest that MPV is an important marker for early detection of atherosclerotic risk in patients with MetS.