A comparative study of azithromycin, cephalexin and penicillin V for the treatment of streptococcal pharyngitis and tonsillitis in children COCUKLARDA STREPTOKOKSIK FARENJIT VE TONSILLIT TEDAVISINDE AZITROMISIN, SEFALEKSIN VE ORAL PENISILIN VNIN ETKINLIGININ KARSILASTIRILMASI

Ece A., Iscan A., Sengil A., Balkan C., Cetinkaya Z.

Mikrobiyoloji Bulteni, vol.30, no.3, pp.233-238, 1996 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 1996
  • Journal Name: Mikrobiyoloji Bulteni
  • Journal Indexes: Scopus
  • Page Numbers: pp.233-238
  • Keywords: Azithromycin, Cephalexin, Penicillin V, Streptococcal pharyngitis/tonsillitis, Treatment
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

In this study, clinical and bacteriological efficacies of penicillin V were compared with those of azithromycin and cephalexin. Of 94 children who had group A beta hemolytic streptococcal (GABHS) pharyngitis/tonsillitis, 31 received a single daily. dose of azithromycin (10 mg/kg) for three days, 33 received cephalexin 40 mg/kg/day in three doses for 10 days, 30 received oral penicillin V 50.000 IU/kg for 10 days. At the end of the treatment, bacterial eradication was achieved in 91% of azithromycin-treated patients, 88% of cephalexin-treated patients and 83% of penicillin treated-patients (p > 0.05). Clinical cure rates were 94% in azithromycin group, 91% in cephalexin group and 90% in penicillin group (p > 0.05). At follow-up evaluation (day 30 ± 5) bacteriologic recurrence was observed in 4 patients of azithromycin-treated group (13%), in 6 of cephalexin treated group (18%) and in 6 of penicillin-treated group (20%). The results of this study indicate that oral penicillin V is clinically as effective as azithromycin and cephalexin in the treatment of GABHS pharyngotonsillitis.