Research Information System
PPAR Research, vol.2007, 2007 (Scopus)
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitivetranscription factors and their dyregulated activations seem to be major culprits for thesepathological processes. Drugs targeting PPARs activity are already in widespread clinical use;however, based on these concepts, this review highlights the understanding of the role ofPPARs in aging and indicates the necessary particular attention for the potential therapeuticuses of current PPAR agonists in age-associated diseases. Copyright © 2007 Adnan Erol.