Prenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung

YÜKSEL H., YILMAZ Ö., Baytur Y. B., Ozbilgin K.

Experimental Lung Research, cilt.34, sa.9, ss.550-558, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/01902140802341736
  • Dergi Adı: Experimental Lung Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.550-558
  • Anahtar Kelimeler: fetal lung maturation, granulocyte-macrophage colony-stimulating factor, vascular endothelial growth factor
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 μg/kg) on day 16 of pregnancy. Rats were sacrificed on days 18 and 20 of gestation. H-score for VEGF was calculated immunohistochemically. Alveolar VEGF expression on days 18 and 20 of gestation was significantly higher in the GM-CSF group (P <.01). Increase in VEGF with prenatal GM-CSF administration indicates that GM-CSF may stimulate lung growth and maturation and may be protective against lung disease due to prematurity. Copyright © Informa Healthcare USA, Inc.