Akademik Veri Yönetim Sistemi
BMC Urology, cilt.25, sa.1, 2025 (SCI-Expanded, Scopus)
Background: Diabetic urinary incontinence is a multifactorial condition involving neuropathy, oxidative stress, and epithelial dysfunction. Serum biomarkers—cathelicidin (LL-37), elafin, vitamin D receptor (VDR), 4-hydroxynonenal (4-HNE), and amyloid-β1–42 (Aβ1–42) may provide insight into underlying mechanisms. Methods: We conducted a cross-sectional, single-centre observational study including 120 adults: type II diabetes with urinary incontinence (DI; n = 40), non-diabetic urinary incontinence (Non-DI; n = 40), and healthy controls (n = 40). Serum biomarker levels were measured by ELISA. Group differences were analysed using Kruskal–Wallis, with pairwise Mann–Whitney U tests and Bonferroni adjustment (m = 3) where appropriate. Results: Among profiled biomarkers, 4-HNE was lower in DI than in both Non-DI and controls, while LL-37, elafin, VDR, and Aβ1–42 showed no Bonferroni-corrected pairwise differences. Conclusion: In diabetic urinary incontinence, 4-HNE showed the most consistent group-level separation—lower in DI compared with both Non-DI and healthy controls—whereas LL-37, elafin, VDR, and Aβ1–42 did not demonstrate Bonferroni-corrected pairwise differences. These preliminary findings highlight oxidative and neuroimmune alterations in diabetic incontinence and warrant validation in larger longitudinal studies.